Background: Therapeutic amniocentesis has been accepted widely as a sa
fe and efficacious way to treat the polyhydramnios-oligohydramnios seq
uence associated with twin-twin transfusion syndrome. Case: A 28-year-
old woman, gravida 2, para 1, diagnosed with twin-twin transfusion syn
drome at 28 weeks' gestation was treated with serial amniocenteses. Th
e dividing membrane was ruptured inadvertently during therapeutic amni
ocentesis, with subsequent complete disruption of the amniotic membran
e. Iatrogenic monoamniotic twins with cord entanglement and knotting r
esulted. Conclusion: Creation of monoamniotic twins by disruption of t
he dividing membrane can be a complication of therapeutic amniocentesi
s for twin-twin transfusion syndrome. Such disruption may result in th
e same morbidity and mortality that are seen in naturally occurring mo
noamniotic twins. (C) 1998 by The American College of Obstetricians an
d Gynecologists.