RAPID PROGRESSION TO INVASIVE CERVIX CANCER IN A WOMAN INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS

Background: Previous studies have shown an increased risk of cervical dysplasia in women infected with human immunodeficiency virus (HIV), a s well as an increased risk of progression to higher-grade lesions. It is not known whether the rate of progression is accelerated over that in immunocompetent women. Case: During September 1991, an HIV-positiv e woman underwent conization of the cervix showing carcinoma in situ. The surgical margins and endocervical curettings were negative for dys plasia. Papanicolaou smears 4 and 7 months after the conization also w ere negative. She then presented 33 months postconization with a stage Ib2 cervical carcinoma, which proved resistant to chemotherapy and pe lvic radiation. Conclusion: Immunosuppression caused by HIV infection may cause a more rapid progression of cervical intraepithelial lesions to carcinoma. (C) 1998 by The American College of Obstetricians and G ynecologists.