THE ROLE OF THE LAWC(P1) MUTATION IN THE REGULATION OF THE WHITE LOCUS EXPRESSION IN DROSOPHILA

The lawc(p1) mutation of the leg-arista-wing complex (lawc) gene alter s expression of three proneural loci: achaete, scute, and cut. In comb ination with the product of the zeste (z) gene, the product of the law c gene regulates expression of the white (w) gene. The -w B3 mutation was genetically analyzed in compounds with various z and w mutations a nd dominant mutations modifying the z-w interaction. The results showe d that lawc(p1) can enhance the transvection effect. The lawc gene was assumed to regulate expression of the white locus at the level of chr omatin condensation.