Jv. Ubeda, NULL HYPOTHESIS OF HUSBAND-WIFE CONCORDANCE OF PARKINSONS-DISEASE IN 1,000 MARRIED-COUPLES OVER AGE 50 IN SPAIN, Neuroepidemiology, 17(2), 1998, pp. 90-95
While the search for environmental neurotoxins as causal factors of Pa
rkinson's disease (PD) continues, we have found no concordance in 1,00
0 married couples over age 50 in Spain. Tn addition, it has been possi
ble to identify a structural grouping of similar chemical characterist
ics that is repeated in the majority of organic compounds that can ind
uce parkinsonism. These compounds have a structural relationship with
the dopamine molecule. The principal epidemiological aspects of PD hav
e a preliminary rational explanation.