SIGNAL-TRANSDUCTION INHIBITORS, HIBARIMICIN-A, HIBARIMICIN-B, HIBARIMICIN-C, HIBARIMICIN-D AND HIBARIMICIN-G PRODUCED BY MICROBISPORA - II - STRUCTURAL STUDIES

Authors
HORI H IGARASHI Y KAJIURA T FURUMAI T HIGASHI K ISHIYAMA T URAMOTO M UEHARA Y OKA T
Citation
H. Hori et al., SIGNAL-TRANSDUCTION INHIBITORS, HIBARIMICIN-A, HIBARIMICIN-B, HIBARIMICIN-C, HIBARIMICIN-D AND HIBARIMICIN-G PRODUCED BY MICROBISPORA - II - STRUCTURAL STUDIES, Journal of antibiotics, 51(4), 1998, pp. 402-417
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
4
Year of publication
1998
Pages
402 - 417
Database
ISI
SICI code
0021-8820(1998)51:4<402:SIHHH>2.0.ZU;2-A
Abstract
The structure of hibarimicins A, B, C, D and G which are inhibitors fo r tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized n aphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was i dentical with angelmicin B.