ACUTE EFFECTS OF HORMONE REPLACEMENT WITH TIBOLONE ON MYOCARDIAL-ISCHEMIA IN WOMEN WITH ANGINA

This study was designed to evaluate whether hormone replacement therap y with tibolone demonstrated similar effects to those observed with oe strogen on myocardial ischaemia and angina. Ten postmenopausal women w ith documented coronary artery disease were evaluated by treadmill exe rcise electrocardiograms before and 24 hours after the oral administra tion of tibolone 2.5 mg. Onset of myocardial ischaemia, as defined by ST segment depression, increased by a median 102 seconds (p=0.022). Ti me to onset of angina increased by 31 seconds (p=0.038), while total e xercise time was not significantly affected (p=0.24). Haemodynamic var iables in the form of heart rate, systolic blood pressure and their pr oduct were unaffected by tibolone administration. We conclude that tib olone appears to show similar anti-ischaemic properties to oestrogen.