Assuming a binary reaction mechanism, the yield of isotopes near the h
eaviest N=Z neutron-deficit nucleus Sn-100 is studied with a microscop
ic transport model. The large influence of nuclear shell structure and
isotope composition of the colliding nuclei on the production of exot
ic nuclei is demonstrated. It is shown that the reaction Fe-54+Cd-106
seems to be most favorable for producing primary exotic Sn isotopes wh
ich may survive if the excitation energy in the entrance reaction chan
nel is less than about 100 MeV. In the case of large differences in th
e charge (mass) numbers between entrance and exit channels the light f
ragment yield is essentially fed from the decay of excited primary hea
vier fragments. The existence of optimal energies for the production o
f some oxygen isotopes in the binary mechanism is demonstrated for the
S-32+Au-197 reaction.