INHIBITION OF ANGIOTENSIN-II RECEPTOR-BINDING BY QUINOLONE ALKALOIDS FROM EVODIA-RUTAECARPA

Authors
LEE HS OH WK CHOI HC LEE JW HANG DO PARK CS MHEEN TI AHN JS
Citation
Hs. Lee et al., INHIBITION OF ANGIOTENSIN-II RECEPTOR-BINDING BY QUINOLONE ALKALOIDS FROM EVODIA-RUTAECARPA, PTR. Phytotherapy research, 12(3), 1998, pp. 212-214
Citations number
16
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
12
Issue
3
Year of publication
1998
Pages
212 - 214
Database
ISI
SICI code
0951-418X(1998)12:3<212:IOARBQ>2.0.ZU;2-L
Abstract
A biologically monitored fractionation of methanol extracts of the fru it of Evodia rutaecarpa led to the isolation of quinolone alkaloids, e vocarpin (1), thyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2) a nd yl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3) as blockers of angiotensin II receptor binding with IC50 values of 43.4 mu M, 34.1 mu M and 48.2 mu M, respectively. (C) 1998 John Wiley & Sons, Ltd.