GASTROINTESTINAL-SPARING ANTIINFLAMMATORY DRUGS - THE DEVELOPMENT OF NITRIC OXIDE-RELEASING NSAIDS

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widel y prescribed medications, but their use continues to be limited by sig nificant toxicity, particularly in the gastrointestinal tract and kidn ey. Better understanding of the pathogenesis of these adverse effects has led to the development of a series of derivatives of standard NSAI Ds that are not only less toxic but more efficacious. The coupling of a nitric oxide-releasing moiety to a range of NSAIDs greatly reduces t heir ability to induce gastrointestinal damage, and greatly increases their tolerability in situations in which there is preexisting gastroi ntestinal inflammation. There is also evidence that these compounds ar e much better tolerated by the kidney. On the other hand, the analgesi c and anti-thrombotic properties of NO-releasing NSAIDs significantly exceed those of the parent drugs. These compounds appear to represent a significant advance in the treatment of inflammation and pain and fo r prophylaxis of thrombotic conditions. (C) 1997 Wiley-Liss, Inc.