HINGE PEPTIDE LIBRARIES IN BASIC RESEARCH AND DRUG DEVELOPMENT - APPLICATION TO BREAST-CANCER AND MULTIPLE-SCLEROSIS

Authors
MOORE GJ
Citation
Gj. Moore, HINGE PEPTIDE LIBRARIES IN BASIC RESEARCH AND DRUG DEVELOPMENT - APPLICATION TO BREAST-CANCER AND MULTIPLE-SCLEROSIS, Drug development research, 42(3-4), 1997, pp. 157-163
Citations number
16
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Drug development research → ACNP
ISSN journal
02724391
Volume
42
Issue
3-4
Year of publication
1997
Pages
157 - 163
Database
ISI
SICI code
0272-4391(1997)42:3-4<157:HPLIBR>2.0.ZU;2-F
Abstract
Libraries of peptides in which a centrally located linker group is int roduced to deliberately disrupt the ordered backbone structure and all ow the flanking amino acid sidechains to cluster together are called ' 'hinge'' or ''hairpin'' peptide libraries. Screening of these librarie s with bioassays directed towards breast cancer and multiple sclerosis has yielded promising new leeds in the search for novel therapeutic e ntities to treat these diseases. (C) 1997 Wiley-Liss, Inc.