MOLECULAR FARMING IN PLANTS - OILSEEDS AS VEHICLES FOR THE PRODUCTIONOF PHARMACEUTICAL PROTEINS

Authors
BOOTHE JG SAPONJA JA PARMENTER DL
Citation
Jg. Boothe et al., MOLECULAR FARMING IN PLANTS - OILSEEDS AS VEHICLES FOR THE PRODUCTIONOF PHARMACEUTICAL PROTEINS, Drug development research, 42(3-4), 1997, pp. 172-181
Citations number
62
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Drug development research → ACNP
ISSN journal
02724391
Volume
42
Issue
3-4
Year of publication
1997
Pages
172 - 181
Database
ISI
SICI code
0272-4391(1997)42:3-4<172:MFIP-O>2.0.ZU;2-5
Abstract
The advantages and limitations of plant-based systems for the producti on of recombinant biopharmaceutical proteins are discussed in the cont ext of other host production systems presently available. A novel appr oach for the purification of recombinant proteins expressed in oilseed s is described that is based on the targeting of these proteins to see d oil bodies. The utility of this approach is demonstrated by the puri fication of the anticoagulant protein hirudin, produced in seeds of Br assica napus. (C) 1997 Wiley-Liss, Inc.