SIMILARITIES BETWEEN THE GENOTOXIC TYPE OF HORMONAL CARCINOGENESIS AND SENESCENCE OF THE REPRODUCTIVE-SYSTEM - ROLE OF SMOKING

The similarity between the biochemical mechanisms of thegenotoxic type of hormonal carcinogenesis and the toxic effect of estradiol on hypot halamic neurones leading to cessation of normal reproductive system fu nctioning (aging) is analyzed. Smoking is considered as a factor promo ting transformation of the promotional type of hormonal carcinogenesis to its genotoxic variant and potentiating neurotoxic/genotoxic effect s of estradiol in the brain, Methods that may prevent genotoxic and ne urotoxic effects of estradiol as well as unfavorable consequences of t he prolonged modifying influence of tobacco smoke are enumerated and s hould be developed further.