Our objective was to test a theoretical model that explains quality of
life as a function of the intrusiveness of illness encroaching on the
different domains of one's life. The intrusiveness of illness is expl
ained not only by disease and treatment related factors, but also by o
ne's psychological and social resources (Devins, 1994). To investigate
this issue, a sample of 336 women aged 50 and under, recently diagnos
ed with breast cancer were interviewed in their homes. Consistent with
Devins' model, intrusiveness of illness mediated the effect of diseas
e and treatment factors on quality of life. Contrary to his model, som
e treatment factors also had direct effects while social and psycholog
ical factors had only direct effects on quality of life. Neither time
post-diagnosis nor type of treatment affected the psychological compon
ent of quality of life. (C) 1998 John Wiley & Sons, Ltd.