THE IMPACT OF L1 RETROTRANSPOSONS ON THE HUMAN GENOME

Authors
KAZAZIAN HH MORAN JV
Citation
Hh. Kazazian et Jv. Moran, THE IMPACT OF L1 RETROTRANSPOSONS ON THE HUMAN GENOME, Nature genetics, 19(1), 1998, pp. 19-24
Citations number
68
Categorie Soggetti
Genetics & Heredity
Journal title
Nature genetics → ACNP
ISSN journal
10614036
Volume
19
Issue
1
Year of publication
1998
Pages
19 - 24
Database
ISI
SICI code
1061-4036(1998)19:1<19:TIOLRO>2.0.ZU;2-R
Abstract
The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vi vo, how its proteins act to retrotranspose other poly A elements and t he extent of its role in shaping the human genome should emerge rapidl y over the next few years. We review the impact of retrotransposons an d how new insight is likely to lead to important practical application s for these intriguing mobile elements.