THE SIGNIFICANCE OF INVOLVED TUMOR BED BIOPSY FOLLOWING WIDE LOCAL EXCISION OF BREAST-CANCER

Citation
I. Taylor et al., THE SIGNIFICANCE OF INVOLVED TUMOR BED BIOPSY FOLLOWING WIDE LOCAL EXCISION OF BREAST-CANCER, European journal of surgical oncology, 24(2), 1998, pp. 110-113
Citations number
13
Categorie Soggetti
Surgery,Oncology
ISSN journal
07487983
Volume
24
Issue
2
Year of publication
1998
Pages
110 - 113
Database
ISI
SICI code
0748-7983(1998)24:2<110:TSOITB>2.0.ZU;2-#
Abstract
Aim. Following wide local excision of breast cancer approximately 25% of patients have residual disease in the tumour bed. The aim of this s tudy was to determine whether positive bed biopsy correlated with eith er local recurrence or overall survival. M Method. Following wide exci sion bed biopsies were taken at four separate sites from the tumour be d. Histopathological assessment of the bed biopsies was made and compa red to features within the primary tumour. Patients were followed-up o ver a median period of 6.17 years and local recurrence and survival da ta documented. Results. Two hundred and sixty-eight patients were incl uded in the study and 63 had positive bed biopsies. In all, 85 patient s had a recurrence of breast cancer and 69 died. Kaplan-Meier plots sh owed no evidence of a difference in survival between bed biospy positi ve and negative patients. Bed biopsy positive patients were at greater risk of local recurrence. Conclusions. These findings suggest that po sitive bed biopsy is associated with an increase in local recurrence r ates but has no effect on overall survival following wide excision of breast cancer.