G-PROTEIN SIGNALING - FINE-TUNING SIGNALING KINETICS

Authors
ZERANGUE N JAN LY
Citation
N. Zerangue et Ly. Jan, G-PROTEIN SIGNALING - FINE-TUNING SIGNALING KINETICS, Current biology, 8(9), 1998, pp. 313-316
Citations number
28
Categorie Soggetti
Biology,Biology
Journal title
Current biology → ACNP
ISSN journal
09609822
Volume
8
Issue
9
Year of publication
1998
Pages
313 - 316
Database
ISI
SICI code
0960-9822(1998)8:9<313:GS-FSK>2.0.ZU;2-R
Abstract
Mammalian 'regulators of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activation, But new eviden ce shows that RGS proteins can also speed up the activation of signali ng. The combined effect is a change in signaling kinetics without a de crease in signaling intensity. (C) Current Biology Ltd ISSN 0960-9822.