GENOMIC STRUCTURE AND CHROMOSOMAL LOCATION OF THE HUMAN TGF-BETA-RECEPTOR INTERACTING PROTEIN-1 (TRIP-I) GENE TO 1P34.1

The human TRIP-1 (transforming growth factor-beta (TGB beta)-receptor interacting protein-1) cDNA encodes a protein able to associate specif ically with the type II TGF beta receptor. It is phosphorylated on ser ine and threonine by this receptor kinase which makes it a strong cand idate as part of the TGF beta signal transduction pathway. we have iso lated the genomic sequence of TRIP-1 and found that the complete codin g region is organised into 11 exons ranging from 39 to 397 bp and span ning approximately 9 kb of genomic DNA. The 5' flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expre ssed gene which is in agreement with its wide pattern of expression. F luorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32. (C) 1998 F ederation of European Biochemical Societies.