In this letter we report the direct perturbative QCD evaluation of twi
st-4 effects in diffractive DIS, They are large and have a strong impa
ct on the Q(2) dependence of diffractive structure functions at large
beta. Based on the AGK rules, we comment on the possible contribution
from diffractive higher twists to proportional to 1/Q(2) corrections t
o proton structure function at small x. These corrections to the longi
tudinal structure function F-L may be particularly large. (C) 1998 Els
evier Science B.V.