TUNING THE AFFINITY OF A SYNTHETIC SIALIC-ACID RECEPTOR USING COMBINATORIAL CHEMISTRY

Authors
PATTERSON S SMITH BD TAYLOR RE
Citation
S. Patterson et al., TUNING THE AFFINITY OF A SYNTHETIC SIALIC-ACID RECEPTOR USING COMBINATORIAL CHEMISTRY, Tetrahedron letters, 39(20), 1998, pp. 3111-3114
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
20
Year of publication
1998
Pages
3111 - 3114
Database
ISI
SICI code
0040-4039(1998)39:20<3111:TTAOAS>2.0.ZU;2-C
Abstract
Combinatorial libraries of carbohydrate receptors were produced by fir st derivatizing poly(allylamine) with the fluorescent boronic acid 1 f ollowed by various mixtures of carboxylic acids. The libraries were sc reened for members that exhibited a larger response for sialic acid th an glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism. (C) 1998 Elsevier Science Ltd. All r ights reserved.