A NOVEL KETONE SYNTHESIS BY A PALLADIUM-CATALYZED REACTION OF THIOL ESTERS AND ORGANOZINC REAGENTS

Authors
TOKUYAMA H YOKOSHIMA S YAMASHITA T FUKUYAMA T
Citation
H. Tokuyama et al., A NOVEL KETONE SYNTHESIS BY A PALLADIUM-CATALYZED REACTION OF THIOL ESTERS AND ORGANOZINC REAGENTS, Tetrahedron letters, 39(20), 1998, pp. 3189-3192
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
20
Year of publication
1998
Pages
3189 - 3192
Database
ISI
SICI code
0040-4039(1998)39:20<3189:ANKSBA>2.0.ZU;2-E
Abstract
A variety of ketones have been prepared by a palladium-catalyzed react ion of ethanethiol esters with organozinc reagents. Various functional groups, including esters, ketones, aromatic halides and aldehydes, to lerate the reaction conditions. The reaction can also be applied to th e synthesis of oc-amino ketones using the corresponding L-alpha-amino thiol esters without racemization. (C) 1998 Elsevier Science Ltd. All rights reserved.