Igc. Coutts et Re. Saint, THE REACTION OF LITHIUM TRIMETHYLSILYLDIAZOMETHANE WITH PYROGLUTAMATES - A FACILE SYNTHESIS OF 6-DIAZO-5-OXO-NORLEUCINE AND DERIVATIVES, Tetrahedron letters, 39(20), 1998, pp. 3243-3246
The reaction of carbamate derivatives of pyroglutamic acid esters with
the lithium salt of trimethylsilyldiazomethane below -100 degrees C g
ives good yields of the corresponding substituted 6-diazo-5-oxo-norleu
cine esters; cleavage of Fmoc-substituted products provides a safe, co
nvenient route to the parent acid. (C) 1998 Elsevier Science Ltd. All
rights reserved.