CARBAMATE-DIRECTED HYDROBORATION - ENANTIOSELECTIVE SYNTHESIS OF THE EXCITATORY AMINO-ACID 1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID

Authors
HODGSON DM THOMPSON AJ WADMAN S
Citation
Dm. Hodgson et al., CARBAMATE-DIRECTED HYDROBORATION - ENANTIOSELECTIVE SYNTHESIS OF THE EXCITATORY AMINO-ACID 1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID, Tetrahedron letters, 39(20), 1998, pp. 3357-3358
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
20
Year of publication
1998
Pages
3357 - 3358
Database
ISI
SICI code
0040-4039(1998)39:20<3357:CH-ESO>2.0.ZU;2-6
Abstract
Carbamate-directed hydroboration (using BH3) of 1-substituted 3-cyclop entenes 2, 6 and 9 and an enantioselective synthesis of the excitatory amino acid 1-aminocyclopentane-1,3-dicarboxylic acid via carbamate-di rected asymmetric hydroboration [90% de, 45% ee using (+)-IpcBH(2)] of cyclopentene 2 are described. (C) 1998 Elsevier Science Ltd. All righ ts reserved.