THE APPLICATION OF DISUBSTITUTED VINYLOGOUS IMINIUM SALTS AND RELATEDSYNTHONS TO THE REGIOCONTROLLED PREPARATION OF UNSYMMETRICAL 2,3,4-TRISUBSTITUTED PYRROLES
Jt. Gupton et al., THE APPLICATION OF DISUBSTITUTED VINYLOGOUS IMINIUM SALTS AND RELATEDSYNTHONS TO THE REGIOCONTROLLED PREPARATION OF UNSYMMETRICAL 2,3,4-TRISUBSTITUTED PYRROLES, Tetrahedron, 54(20), 1998, pp. 5075-5088
Reactions of 2,3-disubstituted chloropropeniminium salts and related s
ynthons with ethyl glycinate, ethyl N-methylglycinate, and ethyl N-ben
zylglycinate have been studied tinder acidic, basic and neutral condit
ions. Such reactions have resulted in efficient and selective methodol
ogy for the synthesis of unsymmetrical 2,3,4-trisubstituted pyrrole sy
stems. (C) 1998 Elsevier Science Ltd. All rights reserved.