Compared with the limited capacity of the human body to store carbohyd
rate (CHO), endogenous fat depots are large and represent a vast sourc
e of fuel for exercise. However, fatty acid (FA) oxidation is limited,
especially during intense exercise, and CHO remains the major fuel fo
r oxidative metabolism. In the search for strategies to improve athlet
ic performance, recent interest has focused on several nutritional pro
cedures which may theoretically promote FA oxidation, attenuate the ra
te of muscle glycogen depletion and improve exercise capacity. In some
individuals the ingestion of caffeine improves endurance capacity, bu
t L-carnitine supplementation has no effect on either rates of FA oxid
ation, muscle glycogen utilisation or performance. Likewise, the inges
tion of small amounts of medium-chain triglyceride (MCT) has no major
effect on either fat metabolism or exercise performance. On the other
hand, in endurance-trained individuals, substrate utilisation during s
ubmaximal [60% of peak oxygen uptake ((V) over dot O-2peak)] exercise
can be altered substantially by the ingestion of a high fat (60 to 70%
of energy intake), low CHO (15 to 20% of energy intake) diet for 7 to
10 days. Adaptation to such a diet, however, does not appear Co alter
the rate of working muscle glycogen utilisation during prolonged, mod
erate intensity exercise, nor consistently improve performance. At pre
sent, there is insufficient scientific evidence to recommend that athl
etes either ingest fat, in the form of MCTs, during exercise, or 'fat-
adapt' in the weeks prior to a major endurance event to improve athlet
ic performance.