NONINVASIVE ASSESSMENT OF STIFFNESS AND FAILURE LOAD OF HUMAN VERTEBRAE FROM CT-DATA

A calculational method based on noninvasively derived data for the ass essment of the mechanical quality of individual vertebrae is presented . Dimensional data obtained from serial, segmented CT scans were used as the geometric input for a newly developed finite element model desi gned to calculate stiffness and failure load of these complex bone str uctures. Mechanical, structural data for cancellous bone was obtained by measurements of the compressive strength and failure load of actual vertebral specimens obtained at autopsy. The stiffness and failure lo ad calculated by the newly developed finite element model were compare d with the data obtained from mechanical measurements of vertebral spe cimens. A high correlation between measured and calculated failure loa d was found (r = 0.89, p < 0.001, n = 16). The correlation between the failure load and bone mineral density (BMD) was significant (r = 0.82 , p < 0.001, n = 16). A similar correlation between calculated and mea sured stiffness (r = 0.81, p < 0.001, n = 15) was also found using the finite element model described herein. Thus the newly developed calcu lation methodology has been verified and can be used to predict the fa ilure load and stiffness of osteoporotic vertebrae using data obtained non-invasively from CT scans.