LATE EFFECTS OF WHOLE-BODY IRRADIATION ON THE INTRANEURONAL METABOLISM OF DOPAMINE AND SEROTONIN

Authors
JOUBERT C JACQUET N LAMBERT F MARTIN S MARTIN C
Citation
C. Joubert et al., LATE EFFECTS OF WHOLE-BODY IRRADIATION ON THE INTRANEURONAL METABOLISM OF DOPAMINE AND SEROTONIN, Journal de chimie physique et de physico-chimie biologique, 95(4), 1998, pp. 788-791
Citations number
7
Categorie Soggetti
Biology,"Chemistry Physical
Journal title
Journal de chimie physique et de physico-chimie biologique → ACNP
Volume
95
Issue
4
Year of publication
1998
Pages
788 - 791
Database
ISI
SICI code
Abstract
Whole-body irradiation leads to delayed cognitive dysfunction which co uld result from perturbations of neurotransmission, specially the dopa minergic and the serotoninergic one. The aim of this study was to dete rmine the concentrations of dopamine (DA), serotonin (5-HT) and their metabolites in three cerebral areas of rats, one month after (neutron- gamma) irradiation at 3,38 Gy. An increase of DA, 5-HT, and their cata bolites was observed. These effects are weak but observed in older rat s.