B. Ramounet et al., DECORPORATION OF TRANSURANIUM ELEMENTS DE PENDING ON THEIR CHEMICAL FORM AND THE WAY OF CONTAMINATION, Journal de chimie physique et de physico-chimie biologique, 95(4), 1998, pp. 857-860
We have measured the efficacy of a local DTPA treatment after intramus
cular administration of Np(IV) and Np(V) into rats, A significant deco
rporation was only observed after contamination with Np(IV) when the c
helator was administered within minutes after contamination, We have a
lso performed a chronic DTPA treatment after exposition of rats to MOX
aerosols, This treatment decreased the extrapulmonary retention of al
pha emitters by a factor of 3-5. These results point out the need of b
iokinetics studies concerning the chelators and the actinides to impro
ve the efficacy of decorporation.