STEREOSELECTIVE SYNTHESIS OF ALCOHOLS - LII - SYNTHESIS OF THE C-10 TO C-18 PART OF THE MYCALAMIDES

A synthesis of the right hand fragment, C-10 to C-18, of mycalamide B is described using three stereogenic centers of D-arabinose. This synt hesis profits from the peculiar conformational properties of the triox a-cis-decalin ring system, which has a high tendency to populate an O- proximal conformation. The described synthesis supersedes earlier atte mpts to reach the right hand fragment of the mycalamides from the C-10 -epi-series.