TOTAL SYNTHESIS OF (-)-MUSCORIDE A - A NOVEL BIS-OXAZOLE BASED ALKALOID FROM THE CYANOBACTERIUM NOSTOC-MUSCORUM

Authors
MUIR JC PATTENDEN G THOMAS RM
Citation
Jc. Muir et al., TOTAL SYNTHESIS OF (-)-MUSCORIDE A - A NOVEL BIS-OXAZOLE BASED ALKALOID FROM THE CYANOBACTERIUM NOSTOC-MUSCORUM, Synthesis, 1998, pp. 613-618
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Year of publication
1998
Pages
613 - 618
Database
ISI
SICI code
0039-7881(1998):<613:TSO(A->2.0.ZU;2-R
Abstract
A convergent total synthesis of the substituted bis-oxazole (-)-muscor ide A (1), isolated from a cyanobacterium, is described based on coupl ing of the N-functionalised ''reverse prenyl'' dipeptide acid 8a to th e threonine-based oxazole 9a, followed by elaboration of the tetrapept ide 7, via the oxazoline-oxazole 16 and the bis-oxazole ester 6.