XANTHONES WITH ANTIMALARIAL ACTIVITY FROM GARCINIA-DULCIS

Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxantho ne (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC50 values of 0.96-3.88 mu g/ml. In addition, revised C-13-NMR assig nments of 3 and complete C-13-NMR assignments of 4 were obtained throu gh analysis of their COSY, NOESY HMQC, and HMBC spectra.