If a factor could be identified which delayed the onset of cataract by
10 years, the number of annual cataract operations worldwide has been
estimated to decrease by 45%. A case-control study compared alcohol c
onsumption in 78 patients attending for routine cataract surgery in So
uth East London with data from a large population-based survey. Male c
ataract patients had a significantly greater risk of being harmful dri
nkers (odds ratio = 8, p = 0.007) than the controls. The harmful male
drinkers were significantly younger than the non-drinkers with catarac
t (mean difference 15 years, p < 0.007). Female cataract patients were
not more likely to be excessive drinkers than controls. The female dr
inkers with cataract were of a similar age to the non-drinking female
patient with cataract. Haematological and biochemical indices of alcoh
ol toxicity indicated five patients who were likely to be harmful drin
kers, but who had denied this on direct questioning. Seven (26%) of th
e male patients had a low serum 25 hydroxycholecalciferol although the
levels were normal in the female patients. These results support the
view that excess alcohol consumption is related to cataract formation
and suggest that alcohol causes premature cataract formation in male,
but not female patients. Alcohol consumption is amenable to interventi
on and suggests that such intervention could have a significant impact
on the need for cataract surgery.