2 NEW MONO-TETRAHYDROFURAN RING ACETOGENINS, ANNOMURICIN-E AND MURICAPENTOCIN, FROM THE LEAVES OF ANNONA-MURICATA

Bioactivity-directed fractionation of the leaf extract of Annona muric ata L. (Annonaceae) has resulted in the isolation of two new Annonaceo us acetogenins, annomuricine (1) and muricapentocin (2). Compounds 1 a nd 2 are monotetrahydrofuran ring acetogenins bearing two flanking hyd roxyl groups; however, each has three additional hydroxyl groups. Comp ound 1 has an erythro 1,2-diol, and 2 has a 1,5,9-triol moiety. Both 1 and 2 showed significant cytotoxicities against six types of human tu mors, with selectivities to the pancreatic carcinoma (PACA-2) and colo n adenocarcinoma (HT-29) cell lines.