CYTOTOXIC SCALARANE SESTERTERPENES FROM A SPONGE, HYRTIOS-ERECTA

Authors
TSUCHIYA N SATO A HATA T SATO N SASAGAWA K KOBAYASHI T
Citation
N. Tsuchiya et al., CYTOTOXIC SCALARANE SESTERTERPENES FROM A SPONGE, HYRTIOS-ERECTA, Journal of natural products, 61(4), 1998, pp. 468-473
Citations number
25
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
4
Year of publication
1998
Pages
468 - 473
Database
ISI
SICI code
0163-3864(1998)61:4<468:CSSFAS>2.0.ZU;2-1
Abstract
Novel scalarane sesterterpenes (1-4) were isolated from a sponge, Hyrt ios erecta (order Dictyoceratida). They were characterized by means of spectral analyses, X-ray crystallography, and chemical reactions. Com pound 1 showed potent in vitro and in vivo antitumor activities. In ad dition, the structure-activity relationship was also discussed using c omputer-assisted structure matching of 1 and aragusterols.