RUBROBRAMIDE, A CYTOTOXIC AND PHYTOTOXIC METABOLITE FROM CLADOBOTRYUM-RUBROBRUNNESCENS

Authors
WAGNER C ANKE H STERNER O
Citation
C. Wagner et al., RUBROBRAMIDE, A CYTOTOXIC AND PHYTOTOXIC METABOLITE FROM CLADOBOTRYUM-RUBROBRUNNESCENS, Journal of natural products, 61(4), 1998, pp. 501-502
Citations number
7
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
4
Year of publication
1998
Pages
501 - 502
Database
ISI
SICI code
0163-3864(1998)61:4<501:RACAPM>2.0.ZU;2-O
Abstract
Cladobotrin (1) and rubrobramide (2) were isolated from the culture fi ltrate of Cladobotryum rubrobrunnescens, a mycophilic deuteriomycete. Rubrobramide (2), possessing a unique oxidized tricyclic system, is a new compound structurally related to flavipucine (3), which also is pr oduced by the fungus. The structure of 2 was determined by spectroscop ic methods. Cladobotrin (1) exhibited weak nematicidal activity toward Meloidogyne incognita, while 2 showed weak cytotoxic and phytotoxic a ctivities.