EFFECT OF BONE WAX EXTRACT ON THE FREQUENCY OF BONE-MARROW ERYTHROCYTE MICRONUCLEI IN MICE

The present study evaluated the induction of micronuclear potency of i ndigenously developed bone wax saline extract. The experiment was desi gned with 2 batches, each consisting of 8 groups with 3 male Swiss alb ino mice each. In each batch, the first 3 groups received Chitra's bon e wax saline extract and the second 3 groups received Johnson & Johnso n bone wax saline extract at 12.5, 25.0 or 50.0 ml/kg body weight ip f or 2 d. The remaining 2 groups were vehicle (saline) and positive (cyc lophosphamide) controls. Animals were sacrificed 24 and 36 h after the second dosing and bone marrow smears were prepared and evaluated for micronuclei. The Chitra's and Johnson & Johnson's bone wax extracts fa iled to induce micronuclei in bone marrow erythrocytes of mice.