A BIOACTIVE SECOSTEROL WITH AN UNUSUAL A-RING AND B-RING OXYGENATION PATTERN ISOLATED FROM AN INDONESIAN SOFT CORAL LOBOPHYTUM SP

Authors
MORRIS LA CHRISTIE EM JASPARS M VANOFWEGEN LP
Citation
La. Morris et al., A BIOACTIVE SECOSTEROL WITH AN UNUSUAL A-RING AND B-RING OXYGENATION PATTERN ISOLATED FROM AN INDONESIAN SOFT CORAL LOBOPHYTUM SP, Journal of natural products, 61(4), 1998, pp. 538-541
Citations number
7
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
4
Year of publication
1998
Pages
538 - 541
Database
ISI
SICI code
0163-3864(1998)61:4<538:ABSWAU>2.0.ZU;2-5
Abstract
A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft cora l Lobophytum sp. The A and B rings of the reported compound 1 have hyd roxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The struct ure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity ag ainst human ovarian tumor and human leukemia cell lines.