Three cases of unilateral retinoblastoma with late bilateralization ar
e presented in this study. The rare occurrence of this event underline
s the need for prolonged follow-up in the fellow-eye, even in the abse
nce of familial retinoblastoma. In these three cases, the first affect
ed eye was enucleated after a diagnosis made at three months, sixteen
months and three years of age. New tumors appeared in the second eye w
hen the children were sixteen years old in one case and five years old
in two cases.