SIGNIFICANCE OF ABNORMALITIES OF CHROMOSOME-5 AND CHROMOSOME-8 IN CHONDROBLASTOMA

Tumor specific chromosomal abnormalities have been identified in sever al histologic subtypes of benign and malignant bone tumors. These anom alies have proven to be useful diagnostically, Characterization of rec urrent chromosomal abnormalities also has provided direction for molec ular investigations of pathogenetically important genes, Cytogenetic r eports of chondroblastoma, a rare benign bone tumor, are few, Cytogene tic analysis of a benign and a malignant chondroblastoma in this study revealed the following abnormal chromosomal complements: 47,XY,+5,t(5 ;5)(p10;q10) and 45, XY,del(2)(p23),del(3)(q23q27),dup(8)(q12q21.), de l(11) (q14q23), -13, add (17) (q25) x 2, respectively, Although a spec ific chromosomal abnormality has not yet emerged for chondroblastoma, abnormalities of chromosomes 5 and 8 have been reported previously in this neoplasm, suggesting preferential involvement of these two chromo somes.