QUINO[8,1-BC][1,4]BENZOXAZEPINONES - HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS

Authors
NAGARAJAN K
Citation
K. Nagarajan, QUINO[8,1-BC][1,4]BENZOXAZEPINONES - HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS, Journal of the Indian Chemical Society, 74(11-12), 1997, pp. 831-833
Citations number
14
Journal title
Journal of the Indian Chemical Society → ACNP
ISSN journal
00194522
Volume
74
Issue
11-12
Year of publication
1997
Pages
831 - 833
Database
ISI
SICI code
0019-4522(1997)74:11-12<831:Q-HRI>2.0.ZU;2-6
Abstract
A series of quinobenzoxazepinones showed activity against the reverse transcriptase of HIV-1. The most potent one was 13 with an amino and m ethyl substitution. Active compounds 5, 12 and 13 inhibited both AZT-s ensitive and AZT-resistant strains of HIV-1 but were inactive against 'pyridone-resistant' HIV-1 and HIV-2. The tricyclic dibenzoxazepine de rivative 23 also showed activity against HIV-1 RT.