THERMODYNAMIC PARAMETERS FOR THE BINDING OF ATP BY PROTONATED OPEN-CHAIN POLYAMINES

The thermodynamic parameters of formation of ATP-protonated polyamine (ethylenediamine, 1,3-diaminopropane, putrescine, cadaverine, diethyle netriamine, spermidine, triethylenetetramine, spermine, tetraethylenep entamine and pentaethylenehexamine) complexes at 25 degrees C have bee n studied by potentiometry (H+-glass electrode and direct calorimetry) . The formation constants of species for two, as yet untested, systems are also included. The thermodynamic parameters were obtained for all the systems studied from log K and Delta H-0 values. It was found tha t ATP-protonated amine complexes are stabilized entropically. Empirica l charge-stability relationships are shown.