THE ANTINOCICEPTIVE EFFECT OF CROTALUS-DURISSUS-TERRIFICUS SNAKE-VENOM IS MAINLY DUE TO A SUPRASPINALLY INTEGRATED RESPONSE

Authors
PICOLO G GIORGI R BERNARDI MM CURY Y
Citation
G. Picolo et al., THE ANTINOCICEPTIVE EFFECT OF CROTALUS-DURISSUS-TERRIFICUS SNAKE-VENOM IS MAINLY DUE TO A SUPRASPINALLY INTEGRATED RESPONSE, Toxicon, 36(1), 1998, pp. 223-227
Citations number
18
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
36
Issue
1
Year of publication
1998
Pages
223 - 227
Database
ISI
SICI code
0041-0101(1998)36:1<223:TAEOCS>2.0.ZU;2-N
Abstract
The antinociceptive effect of Crotalus durissus terrificus snake venom , previously demonstrated in the hot-plate test, was investigated in m ice using the tail-wick model. The venom, administered by the intraper itoneal, subcutaneous or oral route, did not modify the basal latency time to the noxious stimulus and the association of the venom with mor phine did not alter the opioid analgesic effect of this drug. These da ta indicate that the antinociceptive effect of the venom is mainly due to a supraspinally integrated response. (C) 1998 Elsevier Science Ltd . All rights reserved.