Background: Data on chlamydia screening collected as part of Regional
Infertility Prevention Projects often do not include personal identifi
ers, therefore repeat tests for patients during a year cannot be ident
ified. Consequently, positivity is calculated and used to monitor chla
mydia prevalence. Goals: To assess how well positivity can estimate pr
evalence in family planning and sexually transmitted disease (STD) cli
nic settings. Study Design: Analyzed data from chlamydia screening pro
grams in three geographic areas of the United States that used unique
patient identifiers. Results: The relationship between positivity and
prevalence is related to both the percentage of tests that are repeat
tests and the percentage of repeat tests that are positive. On average
, the percentage of positive repeat tests was the same as or higher th
an prevalence in family planning clinics; thus, positivity was the sam
e as or higher than prevalence, In STD clinics, the percentage of posi
tive repeat tests was consistently lower than prevalence; thus, positi
vity underestimated prevalence, However, the absolute difference betwe
en positivity and prevalence was less than 0.5% in family planning and
STD clinics. Conclusions: Positivity can be used to monitor chlamydia
prevalence in women screened in family planning and STD clinic settin
gs.