A 64-year-old man had intense dysphagia and aspiration of 1 month's du
ration. The patient had lower esophageal sphincter (LES) achalasia and
cricopharyngeal dysfunction, with generalized muscle weakness discove
red by neurologic examination. Endoscopy showed no lesions of the mout
h, pharynx, larynx, or esophagus. The diagnosis of achalasia was made
by manometry. The LES did not relax with deglutition; the contractions
in the esophageal body were nonperistaltic and of low amplitude; and
the upper esophageal sphincter pressure did not decrease after degluti
tion. A scintigraphic study of the oral and pharyngeal phases of swall
owing showed a mouth and pharyngeal retention of 90% of the volume swa
llowed.