PERICARDIAL-EFFUSION AND AIDS - BENEFITS OF SURGICAL DRAINAGE

Objectives: During the last few years, AIDS has been the main cause of large pericardial effusions in urban settings. We have therefore had to perform surgical pericardial drainage for diagnostic and/or therape utic purposes in AIDS patients. This study was designed to establish t he diagnostic and therapeutic yield of pericardial drainage for these patients. Methods: We retrospectively reviewed the data of the 13 AIDS patients with a pericardial effusion, referred to our surgical depart ment between December 1989 and December 1996 for surgical drainage and pericardial biopsy. Results: Cytological studies and searches for bac teria, mycobacteria and parasites were all negative. The histology of the 13 pericardial biopsies disclosed three pericardial locations of a Kaposi's sarcoma (all three patients had a pre-existent extra-cardiac location of this sarcoma) and one pericardial location of an already known immature mediastinal teratoma. In the nine other cases, the lesi ons were aspecific. Four patients died of multivisceral failure within 30 days of surgery. For the survivors, surgical drainage afforded rel ief and there were no clinical signs of recurrent effusion. Conclusion s: The cause of pericardial effusion in AIDS is still often unknown, e ven after pericardial biopsy. Here, aspecific pericarditis was the mos t common diagnosis. Although the prognosis of such effusion in these p atients is known to be poor, surgical drainage provided relief for tho se who survived the post-operative period. (C) 1998 Elsevier Science B .V. All rights reserved.