ADAPTATION TO STRESS PREVENTS NITROGEN-OX IDE HYPERPRODUCTION

As was shown earlier, acute hypotensive shock induced by nitrogen oxid e (NO) hyperproduction can be prevented by dosed adaptation to environ mental factors. Ln this work we tested the hypothesis that the mechani sm of this adaptive effect is based on limiting NO hyperproduction. It was shown that rat adaptation to stress completely prevented arterial depression and sharply increased revival rate of the animals after he at shock. Hypotension induced by heat shock was accompanied by almost 2.5-fold increase in NO production (EPR analysis) as compared to the c ontrol. At the background of preadaptation, heat shock did not increas e NO production relative to the animals not subjected to heat shock. T he data obtained agree with the proposal that the adaptation initiates NO-dependent mechanisms of limiting NO hyperproduction. Such limiting seems to be negatively regulated by NO.