HYPOCALCEMIC INDUCED INCREASE IN CREATINE-KINASE IN RATS

Calcium plays an important role in various myopathies, We report on an animal model with increased plasma creatine kinase (CK) resulting fro m hypocalcemia that will provide clues for studying human hypocalcemic myopathy, Male Wistar rats were pair-fed either a control or a calciu m-and vitamin D-3-deficient diet for 1, 2, 3, 4, or 5-6 weeks after we aning (3 weeks old). In the deficient diet-fed rats, plasma creatine k inase was increased and was accompanied by marked hypocalcemia, The om ission of calcium and vitamin D-3 from the diet for 1 or 2 weeks was e nough to cause increased plasma creatine kinase; the creatine kinase r atio of deficient diet-fed rats to controls was 4.84 (1,777 IU L-1/367 IU L-1), and the calcium ion ratio was 0.41 (1.8 mg dL(-1)/4.4 mg dL( -1)) after 2 weeks. These values returned to control levels on treatme nt of the rats,vith the control diet and 1 alpha-OH-vitamin D-3 for 1 week. (C) 1998 by Elsevier Science Inc, All rights reserved.