MICROLISSENCEPHALY

An inbred Arab family with three neonates affected by microlissencepha ly syndrome is reported. Brain magnetic resonance imaging in the index case revealed very thin brain mantle with agyria-pachygyria, agenesis of the corpus callosum, and hypoplasia of the brainstem and cerebellu m. All three neonates had microcephaly, arthrogryposis multiplex conge nita, and micropenis. The presence of three affected newborn infants i n a consanguineous family suggests an autosomal-recessive mode of inhe ritance of this syndrome. The spectrum of microlissencephaly syndrome is reviewed. (C) 1998 by Elsevier Science Inc. All rights reserved.