Objective. A stress-vulnerability model of depression was investigated
in patients with rheumatoid arthritis (RA). Antonovsky's Sense of Coh
erence (SOC) was examined as a factor protecting against depression. M
ethod. Relationships between sociodemographic factors, disease activit
y, functional impairment, pain, depression, and SOC were assessed usin
g multivariate methods in a cross sectional sample of 89 consecutive o
utpatients with RA. Results. Increased prevalence of depression was as
sociated with low SOC and high self-rated pain levels, but not with ot
her factors assessed, By multiple regression analysis, independent con
tributions to depression were observed for SOC (23% of variance) and f
or pain (24% of variance), but not functional impairment or disease ac
tivity. Conclusion. Comprehensive models of adjustment in RA need to i
nclude protective factors such as SOC, in addition to pain and other p
athological variables. SOC may be helpful in identifying individuals w
ith RA who are particularly vulnerable to depression, who may be helpe
d by focused psychological interventions such as cognitive therapy.