Blastomycotic arthritis usually presents as acute monoarticular septic
arthritis resembling a bacterial process. Only 2 cases in the literat
ure have subsequently developed arthritis in a second joint. We descri
be the case of an elderly woman with polyarticular blastomycotic arthr
itis associated with lung, skin, and bone involvement. The organism wa
s identified in the synovial fluid and skin biopsies. Our patient unde
rwent open drainage and aspiration of the involved joints and received
antimycotic therapy.