ARACHIDONIC ACID-SENSITIVE A-CURRENTS AND MULTIPLE KV4 TRANSCRIPTS ARE EXPRESSED IN CHICK CILIARY GANGLION NEURONS

Authors
DRYER L XU ZH DRYER SE
Citation
L. Dryer et al., ARACHIDONIC ACID-SENSITIVE A-CURRENTS AND MULTIPLE KV4 TRANSCRIPTS ARE EXPRESSED IN CHICK CILIARY GANGLION NEURONS, Brain research, 789(1), 1998, pp. 162-166
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
789
Issue
1
Year of publication
1998
Pages
162 - 166
Database
ISI
SICI code
0006-8993(1998)789:1<162:AAAAMK>2.0.ZU;2-X
Abstract
A-currents (I-A) of chick ciliary ganglion (CG) neurons were blocked r eversibly by arachidonic acid and a non-metabolizable analog of arachi donic acid, 5,8,11,14-eicosatetraynoic acid. Inhibition of I-A by both lipids was observed in whole-cell recordings and in excised inside-ou t patches, suggesting that Kv4 (Shal) subunits contribute to functiona l I-A channels in CG neurons. Consistent with this, Kv4.2 and Kv4.3 cD NAs were isolated by RT-PCR from chick CG neurons. (C) 1998 Elsevier S cience B.V.