L. Dryer et al., ARACHIDONIC ACID-SENSITIVE A-CURRENTS AND MULTIPLE KV4 TRANSCRIPTS ARE EXPRESSED IN CHICK CILIARY GANGLION NEURONS, Brain research, 789(1), 1998, pp. 162-166
A-currents (I-A) of chick ciliary ganglion (CG) neurons were blocked r
eversibly by arachidonic acid and a non-metabolizable analog of arachi
donic acid, 5,8,11,14-eicosatetraynoic acid. Inhibition of I-A by both
lipids was observed in whole-cell recordings and in excised inside-ou
t patches, suggesting that Kv4 (Shal) subunits contribute to functiona
l I-A channels in CG neurons. Consistent with this, Kv4.2 and Kv4.3 cD
NAs were isolated by RT-PCR from chick CG neurons. (C) 1998 Elsevier S
cience B.V.